BDBM4213 6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4-yl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::PD173952

SMILES Cn1c2nc(Nc3ccc(cc3)N3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key InChIKey=XZEJMVDCQZRHLN-UHFFFAOYSA-N

Data  5 KI  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 4213   

TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  2.30nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  8.10nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  8.10nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataKi:  8.10nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  55nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  24nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  55nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  100nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  640nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  636nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  8.35nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  98.8nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed