BDBM442776 (R or S)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2-methyl-1-{[7-(trifluoromethyl)imidazo[1,2-c]pyrimidin-5-yl]amino}propan-2-ol and (S or R)-1-[3-Fluoro-4-(trifluoromethyl)phenyl]-2-methyl-1-{[7-(trifluoromethyl)imidazo[1,2-c]pyrimidin-5-yl]amino}propan-2-ol::US10647727, Example 33::US10647727, Example 34

SMILES Cc1cc2nccn2c(N[C@H](c2ccc(c(F)c2)C(F)(F)F)C(C)(C)O)n1

InChI Key InChIKey=HEBDUPRUMNBGAV-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 442776   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 442776BDBM442776(US10647727, Example 34 | (R or S)-1-[3-Fluoro-4-(t...)
Affinity DataKi:  1.33E+3nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 442776BDBM442776(US10647727, Example 34 | (R or S)-1-[3-Fluoro-4-(t...)
Affinity DataKi: >2.96E+3nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2021
Entry Details
US Patent