BDBM448730 US10695337, Example 296::{1-[1-(3-fluoro-4-hydroxybenzoyl)piperidin- 4-yl]-3-[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)- 1H-pyrazol-1-yl]azetidin-3-yl}acetamide

SMILES NC(=O)CC1(CN(C1)C1CCN(CC1)C(=O)c1ccc(O)c(F)c1)n1cc(cn1)-c1ccnc2[nH]ccc12

InChI Key InChIKey=AARBAXZZDWCCNF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 448730   

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 448730BDBM448730(US10695337, Example 296 | {1-[1-(3-fluoro-4-hydrox...)
Affinity DataIC50: 5nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 448730BDBM448730(US10695337, Example 296 | {1-[1-(3-fluoro-4-hydrox...)
Affinity DataIC50: 30nMAssay Description:The catalytic domains of human JAK1 (a.a. 837-1142), Jak2 (a.a. 828-1132) and Jak3 (a.a. 781-1124) with an N-terminal His tag were expressed using ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details
US Patent