BDBM450428 2-[6-[4-(9H- Fluoren-9- ylmethoxycarbonyl) piperazin-1-yl]- 4-oxoquinazolin- 3-yl]acetic acid (intermediate A-1) and 1-(4- chlorophenyl)-N- methylmethanamine ([CAS RN 104- 11-0])::US10676446, Example 43

SMILES CN(Cc1ccc(Cl)cc1)C(=O)Cn1cnc2ccc(cc2c1=O)N1CCN(CC1)C(C)=O

InChI Key InChIKey=QTWYJQLHPAVRFA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 450428   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 450428BDBM450428(US10676446, Example 43 | 2-[6-[4-(9H- Fluoren-9- y...)
Affinity DataIC50: 112nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent