BDBM461171 US10774053, Compound 234

SMILES C[C@H](NC(=O)OC[C@@H](N1C(=N)N[C@@](CC(C)(C)C)(C1=O)c1ccc(cc1)-c1cnn(c1)C1CC1)c1ccc(Cl)c(c1)-n1ncnc1C(F)F)C(F)(F)F

InChI Key InChIKey=DCEJUQPKMPTJSR-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 461171   

TargetEnvelope glycoprotein gp160(HIV-1)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 461171BDBM461171(US10774053, Compound 234)
Affinity DataIC50: 2.20nMAssay Description:Compounds were tested in a high-throughput 384-well assay format for their ability to inhibit the replication of HIV-1 (IIIB) in MT-4 cells. Compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetEnvelope glycoprotein gp160(HIV-1)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 461171BDBM461171(US10774053, Compound 234)
Affinity DataEC50:  9.28nMAssay Description:Assay protocol is identical to that described for the MT-4 antiviral assay with the following changes: Each drug is run in 2 series of quadruplicates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent