BDBM461514 US10774071, Example A-90
SMILES COc1nc(ccc1CN[C@H]1C[C@](C)(O)C1)-c1cccc(c1Cl)-c1cccc2[C@H](CCc12)Nc1nc(OC)c(CN[C@@H](C2CC2)C(O)=O)cc1C(F)(F)F
InChI Key InChIKey=JYNCGHGXMHXZGJ-KEAOCPJPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 461514
TargetProgrammed cell death 1 ligand 1 [19-238]/protein 1 [25-167](Homo sapiens (Human))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataEC50: 31nMAssay Description:Compounds were tested in a functional co-culture reporter assay in which TCR-mediated NFAT activity is inhibited by the engagement of PD-1 with PD-L1...More data for this Ligand-Target Pair
TargetProgrammed cell death 1 ligand 1 [19-238]/protein 1 [25-167](Homo sapiens (Human))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 0.0640nMAssay Description:Compounds were tested in biochemical protein-protein interaction assays to determine if they can specifically block the interaction between the extra...More data for this Ligand-Target Pair