BDBM463212 4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(4- fluorophenyl)methyl]- [1,2,4]triazolo[1,5-a]pyrazin-6- yl}-5-methyl-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin-6-one::US10780092, Example 66-B

SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1cn2ncnc2c(Cc2ccc(F)cc2)n1)c1ccc(O)c(Cl)c1

InChI Key InChIKey=IVNCGKYPWMIGJN-UHFFFAOYSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 463212   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463212(4-Amino-5-(3-chloro-4- hydroxyphenyl)-2-{8-[(4- fl...)
Affinity DataKi:  2.57nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent