BDBM463439 (2S)-2-{[3-amino-1-({4-[(2-oxopyridin-1-yl)methyl]phenyl}methyl)pyrazol-4-::US10781181, Example 116

SMILES C[C@H](NC(=O)c1cn(Cc2ccc(Cn3ccccc3=O)cc2)nc1N)C(=O)N(C)c1cccc(Cl)c1

InChI Key InChIKey=VVRWWUMFOFUNPL-SFHVURJKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463439   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463439((2S)-2-{[3-amino-1-({4-[(2-oxopyridin-1-yl)methyl]...)
Affinity DataIC50: >4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463439((2S)-2-{[3-amino-1-({4-[(2-oxopyridin-1-yl)methyl]...)
Affinity DataIC50:  390nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent