BDBM464650 CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(2-oxo-2-pyrrolidin-1-yl- ethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one::US10793556, Example SC_4077::US10793556, Example SC_4078::US10793556, Example SC_4079::US10793556, Example SC_4080::US10793556, Example SC_4081::US10793556, Example SC_4082

SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1

InChI Key InChIKey=LNOGPNHKBNGOLN-XBMBGIQASA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 464650   

TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  6nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  10nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  10nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  74nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  75nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  125nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  145nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  270nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  415nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  765nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  3.23E+3nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464650(CIS-8-Dimethylamino-3-(2-methylsulfonyl-ethyl)-1-(...)
Affinity DataKi:  4.15E+3nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent