BDBM466556 4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6′-dihydro[2,4′-bipyridin]-1′ (2′H)-yl]ethyl}-cyclohexane-1-carboxamide::US10800755, Example 12::US11014905, Example 12

SMILES FC(F)(F)c1cccc(n1)C1=CCN(CCNC(=O)C2CCC(F)(F)CC2)CC1

InChI Key InChIKey=CFQKEDUZBWAPMC-UHFFFAOYSA-N

Data  3 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 466556   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataKi:  0.200nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(4) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataKi:  4.5nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataKi:  357nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataIC50:  3.50E+3nMAssay Description:The activity of the present compound for inhibiting hERG channel was measured by whole-cell patch clamp method with auto patch clamp system, using CH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(4) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataEC50:  35nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataIC50:  357nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(4) dopamine receptor(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataIC50:  4.5nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataIC50:  0.200nMAssay Description:The binding affinity of the present compounds to human 5-HT1A receptor, human D4 receptor, and human D2 receptor was measured in a manner mentioned b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sumitomo Dainippon Pharma

US Patent
LigandPNGBDBM466556(4,4-Difluoro-N-{2-[6-(trifluoromethyl)-3′,6&...)
Affinity DataEC50: <10nMAssay Description:Aequorin, Gα16 proteins, and each receptor were transiently expressed in CHO-K1 cell (Chinese hamster ovary), and seeded to 384-well plate. The ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent