BDBM466676 5-Methoxy-6-(1-{5-[4- (trifluoromethyl)-phenoxy]-pyridine-2- carbonyl}piperidin-4-yl)-pyridazin-3- amine::US10800757, Compound 91::US10889568, Compound 91

SMILES COc1cc(N)nnc1C1CCN(CC1)C(=O)c1ccc(Oc2ccc(cc2)C(F)(F)F)cn1

InChI Key InChIKey=GLYCHLRZTGETCK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466676   

TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466676(5-Methoxy-6-(1-{5-[4- (trifluoromethyl)-phenoxy]-p...)
Affinity DataIC50:  414nMAssay Description:This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466676(5-Methoxy-6-(1-{5-[4- (trifluoromethyl)-phenoxy]-p...)
Affinity DataIC50:  414nMAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent