BDBM466705 US10800761, Example 24

SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1ccc(cc1N1C[C@@H]2C[C@H]1CN2)-c1cccnc1C

InChI Key InChIKey=VCZPJHYQIPIKSV-PMACEKPBSA-N

Data  3 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 466705   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human carbonic anhydrase II (0.1 nM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataKi:  129nMAssay Description:Inhibitory activity against human carbonic anhydrase II using pH stat assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataIC50:  122nMAssay Description:Compound was evaluated for the inhibition of Spermidine synthase from Escherichia coli and expressed as I50 in uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataIC50:  40nMAssay Description:Histamine H2 receptor antagonism on the right atrium of the guinea pigMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataIC50:  605nMAssay Description:In vitro for inhibition of rat HMG-CoA reductase.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM466705(US10800761, Example 24)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibitory activity against human carbonic anhydrase II using pH stat assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed