BDBM466705 US10800761, Example 24
SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1ccc(cc1N1C[C@@H]2C[C@H]1CN2)-c1cccnc1C
InChI Key InChIKey=VCZPJHYQIPIKSV-PMACEKPBSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 466705
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataKi: <1nMAssay Description:In vitro inhibition of human carbonic anhydrase II (0.1 nM).More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataKi: <100nMAssay Description:A stock solution of 1 mM test compound was prepared in DMSO. The compound plate was prepared by 3-fold and 11-point serial dilutions. 0.1 μL of ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataKi: 129nMAssay Description:Inhibitory activity against human carbonic anhydrase II using pH stat assayMore data for this Ligand-Target Pair
Affinity DataIC50: 122nMAssay Description:Compound was evaluated for the inhibition of Spermidine synthase from Escherichia coli and expressed as I50 in uMMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Histamine H2 receptor antagonism on the right atrium of the guinea pigMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute
Curated by ChEMBL
Incyte Research Institute
Curated by ChEMBL
Affinity DataIC50: 605nMAssay Description:In vitro for inhibition of rat HMG-CoA reductase.More data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibitory activity against human carbonic anhydrase II using pH stat assayMore data for this Ligand-Target Pair