BDBM468322 US10806720, Compound 1002::US11648234, Compound 1022

SMILES C[C@](O)(Cn1cc(F)cn1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=YDRMSDHDYRAUBR-AWEZNQCLSA-N

Data  3 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 468322   

TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [3H] MIB binding to rat prostate androgen receptor LBD by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to rat Androgen receptor ligand binding domain measured by competitive ligand binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-MIB from wild-type rat AR LBD measured after 16 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  199nMAssay Description:Antagonist activity at recombinant human AR expressed in HEK293 cells assessed as inhibition of R1881-induced transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor [633-919](Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  92.2nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  2.00E+3nMAssay Description:SARD activity at AR-LBD F876L mutant (unknown origin) after 4 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  199nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK-293 cells harboring GRE-LUC and CMV-renilla luciferase assessed as inhibition of tran...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor [633-919](Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  199nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  219nMAssay Description:Antagonist activity at recombinant human AR F876L mutant expressed in COS cells assessed as inhibition of R1881-induced transcriptional activity meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  403nMAssay Description:Antagonist activity at recombinant human PR expressed in COS cells assessed as inhibition of R1881-induced transcriptional activity measured after 24...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  199nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468322(US10806720, Compound 1002 | US11648234, Compound 1...)
Affinity DataIC50:  2.00E+3nMAssay Description:SARD activity at AR-LBD T877A mutant (unknown origin) after 4 hrs by luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed