BDBM468334 US10806720, Compound 1015::US11230523, Compound 1015::US11648234, Compound 1015

SMILES C[C@](O)(Cn1ccc(n1)-c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

InChI Key InChIKey=BFRSSNKSUVHGBY-FQEVSTJZSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 468334   

TargetAndrogen receptor(Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468334(US10806720, Compound 1015 | US11230523, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Rattus norvegicus (Rat))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM468334(US10806720, Compound 1015 | US11230523, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-MIB from wild-type rat AR LBD measured after 16 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor [633-919](Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468334(US10806720, Compound 1015 | US11230523, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor [633-919](Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468334(US10806720, Compound 1015 | US11230523, Compound 1...)
Affinity DataKi: >1.00E+4nMAssay Description:hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD was combin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor [633-919](Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468334(US10806720, Compound 1015 | US11230523, Compound 1...)
Affinity DataIC50:  1.74E+3nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468334(US10806720, Compound 1015 | US11230523, Compound 1...)
Affinity DataIC50:  1.07E+3nMAssay Description:Antagonist activity at recombinant human AR expressed in HEK293 cells assessed as inhibition of R1881-induced transcriptional activity measured after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
University of Tennessee Research Foundation

US Patent
LigandPNGBDBM468334(US10806720, Compound 1015 | US11230523, Compound 1...)
Affinity DataIC50:  1.74E+3nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent