BDBM470447 (S)-5-amino-3-(4-((5-chloropyridin-2-yl)oxy)phenyl)-1-(1-cyanopiperidin-3-yl)-1H-pyrazole-4-carboxamide::US10815213, Example 109

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cn2)cc1)[C@H]1CCCN(C1)C#N

InChI Key InChIKey=HECPFMSMYZURCE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 470447   

TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 470447BDBM470447(US10815213, Example 109 | (S)-5-amino-3-(4-((5-chl...)
Affinity DataIC50: 128nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent