BDBM472767 2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile::US10829492, Example 44

SMILES Nc1nn2ccc(nc2c1C#N)N1C[C@@H](O)C[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=OYWAUYQPEXLVTP-IINYFYTJSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 472767   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472767(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-hydrox...)
Affinity DataIC50: <25nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent