BDBM474619 US10849883, Compound 48b::US11559515, Compound 48b

SMILES NC(=O)c1nn(CC(=O)N(CC(=O)NCc2cccc(Cl)c2F)C2CCCC2)c2ccccc12

InChI Key InChIKey=HYLGUMLPCYRSFA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 474619   

TargetComplement factor D(Homo sapiens (Human))
Biocryst Pharmaceuticals

US Patent
LigandPNGBDBM474619(US10849883, Compound 48b | US11559515, Compound 48...)
Affinity DataIC50: <1.00E+3nMAssay Description:An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
Biocryst Pharmaceuticals

US Patent
LigandPNGBDBM474619(US10849883, Compound 48b | US11559515, Compound 48...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human complement factor D using Z-L-Lys-SBzl hydrochloride as substrate preincubated for 15 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetComplement factor D(Homo sapiens (Human))
Biocryst Pharmaceuticals

US Patent
LigandPNGBDBM474619(US10849883, Compound 48b | US11559515, Compound 48...)
Affinity DataIC50: >1.00E+4nMAssay Description:An established esterolytic assay for the measurement of Factor D activity and inhibition of Factor D activity was used (Kam, C. M.; McRae, B. J.; Har...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent