BDBM4777 4-Anilinopyrido[3,4-d]pyrimidine 3::CHEMBL51659::N-{4-[(3-bromophenyl)amino]pyrido[3,4-d]pyrimidin-6-yl}prop-2-enamide

SMILES Brc1cccc(Nc2ncnc3cnc(NC(=O)C=C)cc23)c1

InChI Key InChIKey=OLYVUTGQXNIQQG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4777   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4777(4-Anilinopyrido[3,4-d]pyrimidine 3 | CHEMBL51659 |...)
Affinity DataIC50:  0.910nMpH: 7.4 T: 2°CAssay Description:Enzyme assays for IC50 determinations were performed in 96-well filter plates. IC50 is the inhibitor concentration which inhibits 50% of kinase activ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4777(4-Anilinopyrido[3,4-d]pyrimidine 3 | CHEMBL51659 |...)
Affinity DataIC50:  0.910nMAssay Description:Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University of Auckland

Curated by ChEMBL
LigandPNGBDBM4777(4-Anilinopyrido[3,4-d]pyrimidine 3 | CHEMBL51659 |...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of heregulin-stimulated autophosphorylation of ERBB2 receptor kinase in MDA-MB-453 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of Auckland

LigandPNGBDBM4777(4-Anilinopyrido[3,4-d]pyrimidine 3 | CHEMBL51659 |...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed