BDBM478999 (R)-N-(4-(3-((4-(1-methyl-1H- pyrazol-4-yl)pyrimidin-2- yl)amino)piperidine-1- carbonyl)phenyl)acrylamide::US10894788, Example 39::US11390618, Example 39

SMILES Cn1cc(cn1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)c2ccc(NC(=O)C=C)cc2)n1

InChI Key InChIKey=BUIPKZJUSDFSMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 478999   

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 478999BDBM478999((R)-N-(4-(3-((4-(1-methyl-1H- pyrazol-4-yl)pyrimid...)
Affinity DataIC50: 5.01E+4nMAssay Description:For the assays, 5 μl solution from each well of the compound dilution plates/10% DMSO were transferred into the assay plates. The final volume o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
US Patent

TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 478999BDBM478999((R)-N-(4-(3-((4-(1-methyl-1H- pyrazol-4-yl)pyrimid...)
Affinity DataIC50: 6.50E+4nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
US Patent