BDBM48386 1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanoyl}-4-[3-(trifluoromethyl)phenyl]piperazine::3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-1-propanone::3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one::3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-[3-(trifluoromethyl)phenyl]piperazino]propan-1-one::MLS000091368::SMR000025927::cid_3243472

SMILES COc1ccc(cc1)-c1noc(CCC(=O)N2CCN(CC2)c2cccc(c2)C(F)(F)F)n1

InChI Key InChIKey=VVSHNSYOXKOTJU-UHFFFAOYSA-N

Data  2 KI  1 IC50  10 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 48386   

TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataKi:  410nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetRas-related C3 botulinum toxin substrate 1(Mus musculus)
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataKi:  830nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetGTPase KRas [1-37](Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetRas-related C3 botulinum toxin substrate 1(Mus musculus)
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetRas-related protein Rab-7a(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  1.62E+3nMAssay Description:Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  1.92E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetGTPase KRas [1-37](Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  4.32E+3nMAssay Description:Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetRas-related C3 botulinum toxin substrate 1(Mus musculus)
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  9.14E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetEstrogen receptor beta(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataIC50:  5.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI

TargetRas-related protein Rab-2A(Canis lupus familiaris)
Nmmlsc

Curated by PubChem BioAssay

LigandBDBM48386(1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pro...)Copy SMILESCopy InChI

Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails PCBioAssay
Copy BDB DOI