BDBM484197 CDD-1976::WO2023004291, Compound CDD-1976

SMILES CN(C)C(=O)COc1ccc(cc1C=O)-c1cccc2[nH]ncc12

InChI Key InChIKey=IXTRHVKNNCAPDT-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 484197   

TargetReplicase polyprotein 1ab-His6(2019-nCoV)
Baylor College of Medicine

WIPO
LigandPNGBDBM484197(CDD-1976 | WO2023004291, Compound CDD-1976)
Affinity DataKi:  37nMAssay Description:To evaluate the potency of synthesized compounds against Mpro, the proteolytic activity of 50 nM Mpro -His and Mpro was first measured in the presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails WIPO WO2023004291


TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College of Medicine

LigandPNGBDBM484197(CDD-1976 | WO2023004291, Compound CDD-1976)
Affinity DataKi:  42nMAssay Description:To determine the Ki values of active compounds, 25 nM Mpro was mixed with increasing concentrations of compounds (from 4 nM to 4,000 nM with twofold ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed

TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College of Medicine

LigandPNGBDBM484197(CDD-1976 | WO2023004291, Compound CDD-1976)
Affinity DataKi:  42nMAssay Description:To evaluate the potency of synthesized compounds against Mpro, the proteolytic activity of 50 nM Mpro -His and Mpro was first measured in the presenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails WIPO WO2023004291


TargetReplicase polyprotein 1ab(2019-nCoV)
Baylor College of Medicine

LigandPNGBDBM484197(CDD-1976 | WO2023004291, Compound CDD-1976)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of SARS-CoV-2 replication in VERO E6 and HEK hACE2 cells was measured using an xCELLigence RTCA HT Analyzer (Agilent Technologies), tracki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed