BDBM484443 US10934285, Example 29

SMILES CC[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3cccc(NC(=O)c4c(O)nc5CCCCn5c4=O)c3Cl)c(N)n2)[C@@H]1N

InChI Key InChIKey=LQTJBJPFUSKYGY-GAJHUEQPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 484443   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484443(US10934285, Example 29)
Affinity DataIC50:  12nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent