BDBM486520 US10947251, Example 2

SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1ccc(F)c(c1)C(F)(F)F

InChI Key InChIKey=YPGVISJXRZVLSR-RXVVDRJESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 486520   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM486520(US10947251, Example 2)
Affinity DataIC50:  0.915nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM486520(US10947251, Example 2)
Affinity DataIC50:  38.4nMAssay Description:Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent