BDBM488383 2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- 3-yl)-3-chloro-N-(2-hydroxyethyl)-1H-indole-6- carboxamide::US10954241, Example 23::US11548896, Example 23

SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)NCCO)c2c(N)ncnc12

InChI Key InChIKey=XKSROQSJCOMSFN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 488383   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488383(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50:  14.3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488383(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50:  1.51E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488383(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50:  23.9nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488383(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50:  14.3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488383(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50:  1.51E+3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488383(2-(4-Amino-1-tert-butyl-pyrazolo[3,4-d]pyrimidin- ...)
Affinity DataIC50:  23.9nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent