BDBM488454 2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]pyrimidin-3-yl]-3-chloro-N-methyl-1H-indole-6- carboxamide::US10954241, Example 94::US11548896, Example 94

SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nn(CC2CCOCC2)c2ncnc(N)c12

InChI Key InChIKey=ZBOVSHKBSUTFCS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 488454   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488454(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  13.8nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488454(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  7.67E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488454(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  39.5nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488454(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  13.8nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488454(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  7.67E+3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488454(2-[4-Amino-1-(oxan-4-ylmethyl)-1H-pyrazolo[3,4- d]...)
Affinity DataIC50:  39.5nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent