BDBM488491 (6-((3S,4S)-4- amino-3-methyl-2- oxa-8- azaspiro[4.5]decan- 8-yl)-3-(3-chloro-2- (oxetan-3- yloxy)pyridin-4-yl)- 1H-pyrazolo[3,4- b]pyrazin-5- yl)methanol::US10954243, Example 22

SMILES C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4ccnc(OC5COC5)c4Cl)c3nc2CO)[C@@H]1N

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 488491   

LigandPNGBDBM488491((6-((3S,4S)-4- amino-3-methyl-2- oxa-8- azaspiro[4...)
Affinity DataIC50:  48nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent