BDBM488667 (R)-N-(3-(2-(3- cyclopropylsulfonyl)- 2-fluorophenylamino)- 5-methylpyrimidin-4- yl)-1H-indol-7-yl)-2- (4-methylpiperazin-1- yl)propanamide::US10961228, Example 4

SMILES C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(=O)(=O)C2CC2)ncc1C

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 488667   

TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM488667((R)-N-(3-(2-(3- cyclopropylsulfonyl)- 2-fluorophen...)
Affinity DataIC50: <3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM488667((R)-N-(3-(2-(3- cyclopropylsulfonyl)- 2-fluorophen...)
Affinity DataIC50: >3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM488667((R)-N-(3-(2-(3- cyclopropylsulfonyl)- 2-fluorophen...)
Affinity DataIC50:  1.60E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent