BDBM50001103 (2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic acid::(PMEA)[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid::9-(2-(phosphonomethoxy)ethyl)adenine::9-[(2-phosphonylmethoxy)ethyl]adenine::9-[2-(phosphonomethoxy)ethyl]adenine::9-[2-phosphonomethoxyethyl]adenine::9-[3-(Phosphonomethoxy)ethyl]adenine (PMEA)::ADEFOVIR::CHEMBL484::GS-0393::US10071110, Compound Adefovir::[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid::[2-(6-Amino-purin-9-yl)-ethoxymethyl]-phosphonic acid(PMEA)::[2-(6-amino-9H-purin-9-yl)ethoxy]methylphosphonic acid::{[2-(6-AMINO-9H-PURIN-9-YL)ETHOXY]METHYL}PHOSPHONIC ACID

SMILES Nc1ncnc2n(CCOCP(O)(O)=O)cnc12

InChI Key InChIKey=SUPKOOSCJHTBAH-UHFFFAOYSA-N

Data  2 KI  2 IC50  9 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50001103   

TargetAdenosine deaminase(Bovine)
Academia Sinica

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataKi: >8.00E+5nMAssay Description:Inhibitory activity against adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataKi:  3.00E+6nMAssay Description:Inhibitory activity against PRPP synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHIV-1 protease(Human immunodeficiency virus)
The Regents of The University of California

US Patent
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  1.60E+4nMAssay Description:Preliminary experiments in the inhibition of HIV-1 replication by invention compounds were performed as follows. Drug assays were carried out as prev...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetCapsid scaffolding protein(HHV-5)
The Regents of The University of California

US Patent
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  5.50E+4nMAssay Description:Antiviral assays for HCMV DNA were carried out by DNA hybridization as reported by Dankner, W. M., Scholl, D., Stanat, S. C., Martin, M., Souke, R. L...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetSolute carrier family 22 member 6(Human)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataIC50:  2.80E+4nMAssay Description:TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-1)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  4.75E+4nMAssay Description:Inhibition of herpes simplex virus type 1 thymidine kinase (HSV-1 TK-) B2006 strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-3)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  6.58E+4nMAssay Description:Inhibition of varicella zoster virus thymidine kinase (VZV TK+) YS/R strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-3)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  3.11E+4nMAssay Description:Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) OKA strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-1)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  1.83E+4nMAssay Description:Inhibitory activity against herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) VMW 1837 strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidine kinase(HHV-3)
Academy of Sciences of The Czech Republic

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  1.97E+4nMAssay Description:Inhibitory activity against varicella zoster virus thymidine kinase (VZV TK+) YS strainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetFibroblast growth factor receptor 1(Human)
The Regents of The University of California

US Patent
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  5.50E+4nMAssay Description:Subconfluent human lung fibroblast cells (MRC-5, American Type Culture Collection, Rockville, Md.) in 24-well plates were treated with drugs diluted ...More data for this Ligand-Target Pair
In DepthDetails US Patent


LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataIC50:  3.20E+6nMAssay Description:Inhibitory concentration against Escherichia coli Pyrophosphate Synthetase (PRPP)More data for this Ligand-Target Pair
In DepthDetails Article

TargetCapsid protein(HBV)
Sunshine Lake Pharma

Curated by ChEMBL
LigandPNGBDBM50001103((2-(6-amino-9H-purin-9-yl)ethoxy)methylphosphonic ...)
Affinity DataEC50:  83nMAssay Description:Inhibition of hepatitis B virus capsid assembly infected in human HepG2.215 cells assessed as reduction in viral DNA replication measured on day 7 by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed