BDBM50012060 CHEMBL3263640

SMILES Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)c2nc[nH]c2n1

InChI Key InChIKey=IGXJXMLDIIGDNE-UHFFFAOYSA-N

Data  34 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50012060   

TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK-mediated proliferation in human tonsilar B cells assessed as [3H]thymidine incorporation after 1 hr by liquid scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 8nMAssay Description:Inhibition of full length human wild type his-tagged BTK expressed in Sf9 cells using biotinylated peptide as substrate after 1 hr by Fluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 9nMAssay Description:Inhibition of BTK-induced calcium flux in human Ramos cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 14nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 14nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 30nMAssay Description:Inhibition of BTK in human tonsilar B cells assessed as inhibition of IL6 expression after 1 hr by EIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 36nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 37nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 50nMAssay Description:Inhibition of BTK phosphorylation in human Ramos cells by Western blottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 52nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase TXK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 55nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 112nMAssay Description:Inhibition of BTK-mediated CD86 surface expression in mouse splenic B cells after 18 hrs by antibody-based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 142nMAssay Description:Inhibition of BTK-mediated CD86 surface expression in human peripheral blood mononuclear cells after 18 hrs by antibody-based FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 213nMAssay Description:Inhibition of MAPKAPK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 479nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 3.07E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 9.14E+3nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of MK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of HER1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 1.79E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 3.37E+4nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using benzyloxyresorufin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GSK3B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IKK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012060BDBM50012060(CHEMBL3263640)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2015
Entry Details Article
PubMed