BDBM50015271 CHEMBL3263036

SMILES O=C(Nc1cnn(Cc2cccc(c2)C#N)c1)c1n[nH]c2cc(ccc12)-c1cn[nH]c1

InChI Key InChIKey=LBYBJJIMARLHMV-UHFFFAOYSA-N

Data  3 KI  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50015271   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50015271(CHEMBL3263036)
Affinity DataKi:  0.800nMAssay Description:Inhibition of full-length ITK (unknown origin) using biotin-EQEDEPEGIYGVLF-NH2 as substrate by plate reader analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50015271(CHEMBL3263036)
Affinity DataKi:  1.10nMAssay Description:Inhibition of GST-tagged full length ITK (unknown origin) using BLK peptide as substrate after 35 minsMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50015271(CHEMBL3263036)
Affinity DataKi:  72nMAssay Description:Inhibition of human His-tagged full length AURKA using kemptide peptide as substrate after 60 minsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50015271(CHEMBL3263036)
Affinity DataIC50:  231nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as decrease in phosphorylation of PLC-gamma1 by immunodetection assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50015271(CHEMBL3263036)
Affinity DataIC50:  210nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as reduction in PLC-gamma phosphorylation after 30 minsMore data for this Ligand-Target Pair