BDBM50016897 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2)::2-(2,6-dichloroanilino)-2-imidazoline::CLONIDINE::N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine::clonidine (amino form)

SMILES Clc1cccc(Cl)c1\[#7]=[#6]-1\[#7]-[#6]-[#6]-[#7]-1

InChI Key InChIKey=GJSURZIOUXUGAL-UHFFFAOYSA-N

Data  76 KI  6 IC50  9 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 91 hits for monomerid = 50016897   

TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  0.390nMAssay Description:In vitro rat alpha-2D adrenergic receptor binding using p-aminoclonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  0.390nMAssay Description:Binding affinity towards alpha-2D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  1.70nMAssay Description:Compound was tested for the inhibition of [3H]clonidine binding Alpha-2 adrenergic receptor of crude rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity for human Alpha-2A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]RX821002 from human alpha2 adrenoceptor expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  3.80nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  5.70nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]clonidine from Alpha-2 adrenergic receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  6.20nMAssay Description:Binding affinity towards human Alpha-2B adrenergic receptor by the displacement of [3H]rauwolscineMore data for this Ligand-Target Pair
In DepthDetails

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity towards human Alpha-2A adrenergic receptor by the displacement of [3H]rauwolscineMore data for this Ligand-Target Pair
In DepthDetails

TargetAlpha-2B adrenergic receptor(Rat)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  8.30nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2B adrenergic receptor(Rat)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  8.30nMAssay Description:Binding affinity for rat Alpha-2B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]RX821001 from human alpha2A adrenoceptor expressed in CHO cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNischarin(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  8.90nMAssay Description:Displacement of [3H]-clonidine from bovine imidazoline receptor I-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2B adrenergic receptor(North American opossum)
University of Missouri

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetNischarin(Rat)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  14nMAssay Description:Displacement of [125I] PIC from I1 imidazoline receptor in rat PC12 cells after 45 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor [16-465](Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  25.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  27.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]RS-79948-197 from recombinant human alpha2A adrenoreceptor expressed in CHOK1 cell membrane by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  30nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamste...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  30nMAssay Description:Binding affinity for human Alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  31.6nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  31.6nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetNischarin(wild yak)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  31.6nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]RX821001 from human alpha2B adrenoceptor expressed in CHO cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  35.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAlpha-1A adrenergic receptor(Dog)
Unwersity of Misscuri

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  37nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  39.8nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAlpha-2A adrenergic receptor(Mouse)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  40.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  41.9nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAlpha-2C adrenergic receptor(Rat)
University of California

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  47nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  50.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetNischarin(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  55nMAssay Description:Displacement of [125I]PIC from human imidazoline receptor 1 in human platelets analyzed under norepinephrine mask of alpha 2ARMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  56nMAssay Description:Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscineMore data for this Ligand-Target Pair
In DepthDetails

TargetAlpha-2A adrenergic receptor(Mouse)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  61.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Human)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  61.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  63.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  69.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Pig)
University of Michigan

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  85.1nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  116nMAssay Description:Tested for Binding affinity towards alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1D adrenergic receptor(Human)
Centre De Recherches De Croissy

Curated by PDSP Ki Database
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  126nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

TargetNischarin(Rat)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  126nMAssay Description:Displacement of [125I]PIC from Imidazoline-1 receptor in rat PC12 cell membrane incubated for 30 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  135nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Human)
University of Strasburg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  160nMAssay Description:Binding affinity towards alpha-2C adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2B adrenergic receptor(Rat)
Allergan

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  160nMAssay Description:in vitro alpha-2B adrenergic receptor binding assay from rats ,using RX 821002 as the displaceable ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetNischarin(Rat)
University of Strasbourg

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  282nMAssay Description:Displacement of [3H]paraiodoclonidine from imidazoline I1 receptor in rat PC12 cells after 30 mins by gamma counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  309nMMore data for this Ligand-Target Pair
In DepthDetails PubMed

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