BDBM50042924 CHEMBL1229535

SMILES CC1=C(SC(=NC(=O)C)N1)c2ccc(c(c2)S(=O)(=O)NCCO)Cl

InChI Key InChIKey=JFVNFXCESCXMBC-UHFFFAOYSA-N

Data  1 KI  17 IC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50042924   

LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  4nMAssay Description:Inhibition of PI3K gamma (unknown origin) by membrane capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataKi:  7nMAssay Description:Inhibition of PI3K-gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataKi:  7nMAssay Description:Binding affinity to PI3Kgamma (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay or high-throughput membrane ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 16nMAssay Description:Inhibition of human PI3KCgamma by non-radiometric ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  17nMAssay Description:Inhibition of PI4KB (unknown origin) by membrane capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details PDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 17nMAssay Description:Inhibition of histidine-tagged recombinant human full length PI3Kgamma expressed in insect cells preincubated for 15 mins followed by addition of col...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 19nMAssay Description:Inhibition of PI4KIIIbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 19nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 28nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  39nMAssay Description:Inhibition of PI3K alpha (unknown origin) by membrane capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 39nMAssay Description:Inhibition of PI3K alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Curtin University

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 64nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Curtin University

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 64nMAssay Description:Inhibition of human DNA-PK by non-radiometric ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 77nMAssay Description:Inhibition of histidine-tagged recombinant human full length PI3Kdelta expressed in baculovirus preincubated for 15 mins followed by addition of cold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 140nMAssay Description:Inhibition of human PI3KC2beta by non-radiometric ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  140nMAssay Description:Inhibition of PIK3C2B (unknown origin) by membrane capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  220nMAssay Description:Inhibition of human VPS34 assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P ELIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  307nMAssay Description:Inhibition of human VPS34 assessed as reduction in PIP3 product complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 307nMAssay Description:Inhibition of GST-tagged recombinant human full length VPS34 expressed in baculovirus preincubated for 15 mins followed by addition of cold ATP/gamma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2017
Entry Details Article
PubMed
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 320nMAssay Description:Inhibition of full length human recombinant VPS34 (unknown origin) using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  539nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  590nMAssay Description:Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  590nMAssay Description:Inhibition of PI3K beta (unknown origin) by membrane capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of PI4KA (unknown origin) by membrane capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PI4K3alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of PI3KC2beta (unknown origin) expressed in HEK293 cells using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human PI3KC2alpha by non-radiometric ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of PIK3C2A (unknown origin) by membrane capture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PI3KC2alpha (unknown origin) expressed in HEK293 cells using phosphatidylinositol and gamma-32P-ATP incubated for 20 mins by TLC assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/14/2018
Entry Details Article
PubMed