BDBM50051793 (2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylamino)-acetyl]-5-p-tolyl-pyrrolidine-2-carboxylic acid::CHEMBL315037

SMILES Cc1ccc(cc1)[C@H]2CC[C@H](N2C(=O)CNC(=O)[C@H](Cc3ccccc3)S)C(=O)O

InChI Key InChIKey=LQAZEFOQORVDKT-UHFFFAOYSA-N

Data  5 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50051793   

TargetAngiotensin-converting enzyme(Human)
University of Bath

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051793BDBM50051793((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human glycosylated C-terminal catalytic ACE domain using Cbz-Phe-His-Leu substrate by fluorogenic end point activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAngiotensin-converting enzyme(Rat)
University of Paris

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051793BDBM50051793((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataIC50: 6.80nMAssay Description:In vitro inhibition of rat angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNeprilysin(Human)
University of Bath

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051793BDBM50051793((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human NEP ectodomain using MCA-RPPGFSAFK-(Dnp)-OH peptide as substrate by continuous activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNeprilysin(Rabbit)
University of Paris

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051793BDBM50051793((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataIC50: 13nMAssay Description:In vitro inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Bath

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50051793BDBM50051793((2S,5R)-1-[2-((S)-2-Mercapto-3-phenyl-propionylami...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human glycosylated N-terminal catalytic ACE domain using Cbz-Phe-His-Leu substrate by fluorogenic end point activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)