BDBM50054107 CHEMBL3319533

SMILES Cn1cc(cn1)-c1cc(cnc1N1CCN(CC1)S(=O)(=O)c1ccc(N)nc1)C(O)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=HYRZJDXFIXBPRU-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50054107   

TargetHexokinase-4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50054107(CHEMBL3319533)
Affinity DataIC50:  1nMAssay Description:Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Mus musculus (Mouse))
Amgen

Curated by ChEMBL
LigandPNGBDBM50054107(CHEMBL3319533)
Affinity DataEC50:  52nMAssay Description:Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50054107(CHEMBL3319533)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50054107(CHEMBL3319533)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed