BDBM50056928 3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,4]dioxepin-11-one::CHEMBL368810::NSC-31867

SMILES CCCCCc1cc(O)cc2OC(=O)c3c(Oc12)cc(O)cc3C(=O)CCCC

InChI Key InChIKey=ZSMRNRJMUKTCNH-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50056928   

TargetKinesin-like protein KIF20B(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056928(3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,...)
Affinity DataIC50:  1.87E+4nMAssay Description:Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in Escherichia coli B...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF20B(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056928(3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,...)
Affinity DataIC50:  2.44E+4nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (57 to 491 residues) expressed in E...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF20B(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056928(3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of basal ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056928(3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,...)
Affinity DataIC50:  3.92E+4nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056928(3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,...)
Affinity DataIC50:  5.99E+4nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056928(3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,...)
Affinity DataIC50:  2.81E+4nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056928(3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,...)
Affinity DataIC50:  4.22E+4nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF20B(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50056928(3,8-Dihydroxy-1-pentanoyl-6-pentyl-dibenzo[b,e][1,...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of microtubule-stimulated ATPase activity of N-terminal His6-tagged/SUMO-fused human MPP1 motor domain (2 to 477 residues) expressed in Es...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed