BDBM50063373 1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazin-1-yl]-2-piperidin-4-yl-ethanone::CHEMBL352918

SMILES Clc1ccc2C(N3CCN(CC3)C(=O)CC3CCNCC3)c3ncc(Br)cc3CCc2c1

InChI Key InChIKey=VOCBHZWNUHMROR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50063373   

LigandPNGBDBM50063373(1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...)
Affinity DataIC50: >3.80E+4nMAssay Description:Inhibition of rat Geranylgeranyl transferase (GGPT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063373(1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...)
Affinity DataIC50:  72nMAssay Description:In vitro inhibition of farnesyltransferase farnesylation of the H-ras oncogeneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50063373(1-[4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]c...)
Affinity DataIC50:  170nMAssay Description:Inhibition of Farnesyltransferase from Ras-CVLS or Ras-CVLL in Cos-7 monkey kidney cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed