BDBM50077556 1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]thiadiazol-3-yl}-4-aza-tricyclo[2.2.1.0*2,6*]heptane::CHEMBL60777

SMILES Fc1cc(Cl)cc(c1)C#CCOc1nsnc1C12CN3CC1C2C3

InChI Key InChIKey=INFRTOXKNDVOFT-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50077556   

TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50077556(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynyloxy]...)
Affinity DataEC50:  1.48E+3nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
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Curated by ChEMBL
LigandPNGBDBM50077556(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynyloxy]...)
Affinity DataIC50:  92nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
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Curated by ChEMBL
LigandPNGBDBM50077556(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynyloxy]...)
Affinity DataEC50:  110nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed