BDBM50080234 3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyridin-3-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid::CHEMBL40073

SMILES CC(C)(C)Sc1c(CC(C)(C)C(O)=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cccnc3)cc12

InChI Key InChIKey=WWCSZUZAGBMLQG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50080234   

TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Merck Frosst Center For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50080234(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyr...)
Affinity DataIC50:  59nMAssay Description:Measuring the affinity of leukotriene synthesis inhibitor for 5-lipoxygenase activating protein by using [125I]-L-691,831 as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080234(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyr...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of calcium ionophore (A23187) stimulated LTB4 formation in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50080234(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(pyr...)
Affinity DataIC50:  1.09E+3nMAssay Description:Human whole blood was stimulated with calcium ionophore (A23187) and LTB 4 measured by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article