BDBM50090505 (1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione::(1R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione::(1S,2R,6S,7R)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione::(1S,3S,4R,7R)-2,6-dimethyl-4,10-dioxa-tricyclo[5.2.1.0-2,6]decane-3,5-dione::CANTHARIDIN::CHEMBL48449::cid_6708701

SMILES C[C@]12[C@@H]3CC[C@@H](O3)[C@@]1(C)C(=O)OC2=O

InChI Key InChIKey=DHZBEENLJMYSHQ-XCVPVQRUSA-N

Data  16 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50090505   

TargetMu-type opioid receptor(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  272nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  8.00E+3nMAssay Description:Compound was tested for inhibitory concentration of Protein Phosphatase 2A (PP2A).More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein phosphatase 1B(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  1.78E+3nMAssay Description:Inhibitory activity against recombinant Protein phosphatase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  260nMAssay Description:Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein phosphatase 1B(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against protein phosphatase-1 from rabbit skeletal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  1.70E+3nMAssay Description:Concentration required to inhibit the action of protein phosphatase 2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  360nMAssay Description:Inhibitory concentration against protein phosphatase 2A was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibitory concentration against protein phosphatase 1 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  260nMAssay Description:Inhibition of Serine/threonine protein phosphatase 2A by anhydride modified Cantharidin analoguesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  1.78E+3nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 by anhydride modified Cantharidin analoguesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  200nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform(Bovine)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at rat H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after 6 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  600nMAssay Description:Antagonist activity at rat H3 receptor expressed in human SK-N-MC cells assessed as inhibition of forskolin-induced cAMP accumulation after 6 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein phosphatase 6 catalytic subunit(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at mouse histamine H4 receptor in SK-N-MC cells assessed as inhibition of forskolin-stimulated cAMP release preincubated for 10 m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrans-activator protein BZLF1(HHV-4)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50090505((1R,2S,6R,7S)-2,6-Dimethyl-4,10-dioxa-tricyclo[5.2...)
Affinity DataIC50:  239nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay