BDBM50110164 (Z)-2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-methyl-3H-inden-1-yl)acetic acid::2-(3-(4-(methylthio)benzylidene)-6-fluoro-2-methyl-3H-inden-1-yl)acetic acid::CHEMBL18797::SULINDAC SULFIDE::Sulindac sulphide::[6-Fluoro-2-methyl-3-(4-methylsulfanyl-benzylidene)-3H-inden-1-yl]-acetic acid::cid_5352624::{6-Fluoro-2-methyl-3-[1-(4-methylsulfanyl-phenyl)-meth-(E)-ylidene]-3H-inden-1-yl}-acetic acid::{6-Fluoro-2-methyl-3-[1-[4-(methyl-lambda*4*-sulfanyl)-phenyl]-meth-(E)-ylidene]-3H-inden-1-yl}-acetic acid
SMILES CSc1ccc(\C=C2\C(C)=C(CC(O)=O)c3cc(F)ccc23)cc1
InChI Key InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50110164
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataKi: 2.70E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
Affinity DataKi: 3.50E+3nMAssay Description:Binding affinity towards human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.85E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
Affinity DataKi: 5.11E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc
Curated by PubChem BioAssay
Nmmlsc
Curated by PubChem BioAssay
Affinity DataKi: 7.52E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology
Curated by ChEMBL
Vanderbilt University Center For Structural Biology
Curated by ChEMBL
Affinity DataEC50: 800nMAssay Description:Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by lucifer...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant COX2 after 5 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Zafes/Liff/Goethe University Frankfurt
Curated by ChEMBL
Zafes/Liff/Goethe University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of ovine COX1 after 5 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.15E+5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 40 production by luciferase...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.25E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing APP Swedish mutant assessed as inhibition of amyloid beta 42 production by luciferase...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of gamma-secretase in HEK293 cells co-overexpressing NotchdeltaE assessed as inhibition of notch cleavage by luciferase reporter gene assa...More data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.32E+5nMAssay Description:Displacement of [3H]IN973 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Okayama University Graduate School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.71E+4nMAssay Description:Displacement of [3H]L685458 from gamma-secretase in human THP1 cellsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Vanderbilt University Center For Structural Biology
Curated by ChEMBL
Vanderbilt University Center For Structural Biology
Curated by ChEMBL
Affinity DataEC50: 800nMAssay Description:Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as transc...More data for this Ligand-Target Pair
Affinity DataEC50: 5.47E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
Affinity DataEC50: 5.33E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
Affinity DataEC50: 4.12E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc
Curated by PubChem BioAssay
Nmmlsc
Curated by PubChem BioAssay
Affinity DataEC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
TargetCell division control protein 42 homolog(Homo sapiens (Human))
Nmmlsc
Curated by PubChem BioAssay
Nmmlsc
Curated by PubChem BioAssay
Affinity DataEC50: 4.86E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition by microplate reader...More data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: NIH I RO3 MH081231-01 HTS to identify specific small molecule inhibitors of Ras and Ras-rela...More data for this Ligand-Target Pair