BDBM50111472 CHEMBL3604921

SMILES C=CC(=O)Nc1cccc(Oc2nc(Nc3cc(C)[nH]n3)cc(N3CCN(C)CC3)n2)c1

InChI Key InChIKey=PSWJMRDJPWAQDI-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50111472   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tu Dortmund University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111472BDBM50111472(CHEMBL3604921)
Affinity DataIC50: 28nMAssay Description:Inhibition of cSrc T338M/S345C mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Tu Dortmund University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111472BDBM50111472(CHEMBL3604921)
Affinity DataIC50: 170nMAssay Description:Inhibition of cSrc T338M mutant (unknown origin) pre-incubated for 30 mins before substrate and ATP addition by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Tu Dortmund University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111472BDBM50111472(CHEMBL3604921)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin) expressed in Sf9 cells pre-incubated for 30 mins before substrate and ATP addition by homogeneous time-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2016
Entry Details Article
PubMed