BDBM50114585 (R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL47203

SMILES CN1CCN(CC1)[C@H]1CC[C@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=FDVSOQRNTAPCHB-ZRZAMGCNSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50114585   

TargetInsulin receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of insulin receptor kinase (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human p55 Fyn tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human B lymphoid tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human Tyrosine-protein kinase CSKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human p56 Lyn tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70kDa, Zap70 (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  250nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  42nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of cMet kinase (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  1.19E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Cell division control protein 2, Cdk-1 (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50114585((R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed