BDBM50114585 (R)-7-[4-(4-Methyl-piperazin-1-yl)-cyclohexyl]-5-(4-phenoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine::CHEMBL47203
SMILES CN1CCN(CC1)[C@H]1CC[C@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12
InChI Key InChIKey=FDVSOQRNTAPCHB-ZRZAMGCNSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50114585
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of insulin receptor kinase (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of human p55 Fyn tyrosine kinase.More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of human B lymphoid tyrosine kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of human Tyrosine-protein kinase CSKMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of human p56 Lyn tyrosine kinaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70kDa, Zap70 (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of TIE-2 kinaseMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of cMet kinase (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Cell division control protein 2, Cdk-1 (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Abbott Bioresearch Center
Curated by ChEMBL
Abbott Bioresearch Center
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of Platelet-derived growth factor receptor (Inactive at 1 mM ATP)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair