BDBM50115572 (Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid::4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-enoic acid::CHEMBL108253::CHEMBL18927::CHEMBL492770

SMILES OC(=O)C(=O)CC(=O)c1cccc(OCc2ccccc2)c1

InChI Key InChIKey=FCBLTJFBERTVBY-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50115572   

TargetRNA-directed RNA polymerase(Hepatitis C virus)
Italy. Vinc

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory activity against Hepatitis C virus RNA dependent RNA polymerase nonstructural protein 5BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory concentration of the compound was determined against Recombinant HIV-1 integrase (3'processing)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Integrase (3'-processing) as measured in an in vitro assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Italy. Vinc

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  8.00E+3nMpH: 7.5Assay Description:Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  350nMAssay Description:Strand transfer inhibitory activity against HIV-1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of SCV helicase assessed as duplex-DNA unwinding by FRET based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  350nMAssay Description:Inhibitory effect on strand transfer of proviral DNA into host DNA in an extracellular HIV-1 integrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  6.50E+4nMAssay Description:Inhibitory effect on 3'-processing(3'-P) of proviral DNA in an extracellular HIV-1 integrase assay in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory effect on 3'-processing(3'-P) of proviral DNA in an extracellular HIV-1 integrase assay in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50:  350nMAssay Description:Inhibitory concentration against Recombinant HIV-1 integrase (Standard transfer reaction)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Konkuk University

Curated by ChEMBL
LigandPNGBDBM50115572((Z)-4-(3-Benzyloxy-phenyl)-2-hydroxy-4-oxo-but-2-e...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed