BDBM50134784 CHEMBL526243::TCMDC-137820

SMILES Nc1nc(N)c2c3ccn(Cc4ccc(cc4)C#N)c3ccc2n1

InChI Key InChIKey=IZYHVTAYLHFZSP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50134784   

TargetDihydrofolate reductase(Lactobacillus casei)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of DHFR in Lactobacillus casei using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluoromet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of rat DHFR extracted from liver using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorom...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  10nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli assessed as reduction in consumption of NADPH using DHF as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50134784(CHEMBL526243 | TCMDC-137820)
Affinity DataIC50:  4nMAssay Description:Inhibition of DHFR in mouse L1210 cells using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorometri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed