BDBM50134784 CHEMBL526243::TCMDC-137820
SMILES Nc1nc(N)c2c3ccn(Cc4ccc(cc4)C#N)c3ccc2n1
InChI Key InChIKey=IZYHVTAYLHFZSP-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50134784
TargetDihydrofolate reductase(Lactobacillus casei)
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataIC50: 6.40nMAssay Description:Inhibition of DHFR in Lactobacillus casei using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluoromet...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of rat DHFR extracted from liver using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorom...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mycobacterium tuberculosis)
National University of Singapore
Curated by ChEMBL
National University of Singapore
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of Mycobacterium tuberculosis H37Rv DHFR expressed in Escherichia coli assessed as reduction in consumption of NADPH using DHF as substrat...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University of Singapore
Curated by ChEMBL
National University of Singapore
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human DHFR assessed as reduction in consumption of NADPH using DHF as substrate by fluorescence methodMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Mus musculus (Mouse))
Oregon Health & Science University
Curated by ChEMBL
Oregon Health & Science University
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of DHFR in mouse L1210 cells using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorometri...More data for this Ligand-Target Pair