BDBM50146166 CHEMBL3765306
SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1
InChI Key InChIKey=BIEQEAYPFKISHJ-UHFFFAOYSA-O
Data 22 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 50146166
Affinity DataIC50: 1.90nMAssay Description:Inhibition of c-Met (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human COLO205 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of VEGFR-2 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of VEGFR-3 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.80nMAssay Description:Inhibition of HGF induced c-Met phosphorylation in human A549 cells after 10 mins by Western blot analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.860nMAssay Description:Inhibition of VEGF induced VEGFR2 phosphorylation in HUVEC after 5 mins by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human SNU5 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in HUVEC assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human SNU638 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human MKN45 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human EBC1 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human NUGC4 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human Hs 746T cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human OE33 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human KATO III cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human SNU620 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human SNU668 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human U87MG cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human SNU484 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human AGS cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80nMAssay Description:Inhibition of constitutively activated c-Met phosphorylation in human A549 cells assessed as cell viability after 72 hrs by CCK8 assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Inhibition of VEGFR-1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair