BDBM50150818 CHEMBL3774575

SMILES CCCOc1cc(cc(c1)Oc2cc3c(cc2NS(=O)(=O)c4ccc(c(c4)OC)OC)N(C(=O)N3C)C)OCCCCN(C)C

InChI Key InChIKey=HYQBRUSSCIAOOD-UHFFFAOYSA-N

Data  2 IC50  10 Kd  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50150818   

TargetTranscription intermediary factor 1-alpha(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human TRIM24-PHD/bromodomain expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeregrin(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to recombinant human BRPF1 expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of recombinant human His-tagged TRIM24-PHD/bromodomain expressed in Escherichia coli strains BL21 (DE3) cells using biotinylated H3K23ac (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 1(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd:  12nMAssay Description:Binding affinity to recombinant human BRPF2 expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetPeregrin(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd:  14nMAssay Description:Binding affinity to BRPF1 (unknown origin) expressed in Escherichia coli strains BL21 (DE3) cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetBromodomain and PHD finger-containing protein 3(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd:  27nMAssay Description:Binding affinity to recombinant human BRPF3 expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetTranscription intermediary factor 1-alpha(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd:  31nMAssay Description:Binding affinity to recombinant human His-tagged TRIM24-PHD/bromodomain expressed in Escherichia coli strains BL21 (DE3) cells by isothermal titratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription intermediary factor 1-alpha(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataEC50:  50nMAssay Description:Inhibition of Flag-tagged TRIM24-PHD/bromodomain (unknown origin) expressed in human HeLa cells for 2 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTranscription intermediary factor 1-alpha(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataIC50: 150nMAssay Description:Inhibition of TRIM24 (unknown origin) measured alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain adjacent to zinc finger domain protein 2B(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd:  400nMAssay Description:Binding affinity to recombinant human BAZ2B expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity to recombinant human TAF1 bromodomain 2 expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to recombinant human BRD4 long isoform bromodomain 2 expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
The University of Texas M.D. Anderson Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50150818BDBM50150818(CHEMBL3774575)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to recombinant human BRD4 long isoform bromodomain 1 expressed in bacterial system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2017
Entry Details Article
PubMed