BDBM50174702 (R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-3-oxoprop-1-enyl)-5-chlorophenyl)acetamide::CHEMBL198949

SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)\C=C\c1ccc(Cl)cc1NC(C)=O

InChI Key InChIKey=DUFKTZBQJIHIAQ-VGZDNEPHSA-N

Data  34 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50174702   

TargetC-C chemokine receptor type 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  1nMAssay Description:Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human adrenergic alpha-2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human adrenergic beta-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human delta opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human 5HT7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human muscarinic receptor M4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human 5HT3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human muscarinic receptor M5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CCR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human adrenergic alpha-2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human 5HT1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human adrenergic alpha-2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CCR6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human dopamine receptor D4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  320nMAssay Description:Antagonistic activity at rat CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of mouse CCR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human muscarinic receptor M2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human muscarinic receptor M3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CCR2bMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  580nMAssay Description:Antagonistic activity at mouse CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human muscarinic receptor M1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human 5HT1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50174702((R)-N-(2-(3-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  30nMAssay Description:Antagonistic activity at human CCR1 in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed