BDBM50186426 CHEMBL210858::US10336721, ISO-1::US10968198, ISO-1::US8618147, ISO-1::methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate
SMILES COC(=O)CC1CC(=NO1)c1ccc(O)cc1
InChI Key InChIKey=AIXMJTYHQHQJLU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50186426
Affinity DataKi: 2.10E+4nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 2.10E+4nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
Affinity DataKi: 4.35E+4nMAssay Description:Inhibition of MIF tautomerase (unknown origin) using 4-HPP as substrate preincubated for 1 hr followed by substrate addition by Lineweaver-Burk plot ...More data for this Ligand-Target Pair
Affinity DataKi: 4.40E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
Affinity DataKi: 4.40E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF tautomerase activity expressed in Escherichia coli BL21 using 4-hydroxyphenyl pyruvic acid ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of recombinant human MIF (Pro2 to Ala115 residues) expressed in Escherichia coli using dopachrome methyl ester as substrate preincubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of recombinant MIF (unknown origin) tautomerase activity using dopachrome methyl ester as substrate measured for 2 to 20 secs by spectroph...More data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human MIF tautomerase activity expressed in Escherichia coli BL21 using 4-hydroxyphenyl pyruvic acid ...More data for this Ligand-Target Pair
Affinity DataKd: 4.70E+4nMAssay Description:Displacement of 4'-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-[1,1'-biphenyl]-4-carboxylic acid from C-terminal His-tagged recombinant human MIF expressed in ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.53E+4nMAssay Description:Inhibition of MIF tautomerase (unknown origin) using 4-HPP as substrate preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of recombinant His-tagged MIF tautomerase activity (unknown origin) using 4-HPP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+4nMAssay Description:Inhibition of dopachrome tautomerase activity of MIF in human THP1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of dopachrome tautomerase activity of human recombinant MIFMore data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Mus musculus (Mouse))
The Feinstein Institute For Medical Research
US Patent
The Feinstein Institute For Medical Research
US Patent
Affinity DataIC50: 1.10E+4nMpH: 7.2 T: 2°CAssay Description:MIF tautomerase activity was measured by UV-Visible recording spectrophotometry (SHIMADZU, UV1600U). A fresh stock solution of L-dopachrome methyl es...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of MIF tautomerase activityMore data for this Ligand-Target Pair