BDBM50203246 CHEMBL3953119::US11530198, Example 2
SMILES Nc1ncc(N2CCN(CC2)c2cccc(c2)-c2ccccc2)c(N)n1
InChI Key InChIKey=MDKTZILMEGSDQH-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50203246
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant human DHFR expressed in Escherichia coli preincubated for 15 mins followed by addition of DHF as substrate and NADPH measur...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Turing Pharmaceuticals
Curated by ChEMBL
Turing Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8.70nMAssay Description:Inhibition of Toxoplasma gondii TS-DHFR expressed in Escherichia coli BL21 preincubated for 15 mins followed by addition of DHF as substrate and NADP...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Turing Pharmaceuticals
Curated by ChEMBL
Turing Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 689nMAssay Description:Inhibition of human DHFR expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed by substrate and...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Turing Pharmaceuticals
Curated by ChEMBL
Turing Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of Toxoplasma gondii DHFR-TS expressed in Escherichia coli BL21 competent cells using DHF as substrate preincubated for 15 mins followed b...More data for this Ligand-Target Pair