BDBM50206092 CHEMBL3917143::US10336721, Example 32::US10968198, Example 32

SMILES OC(=O)c1cccc(Oc2cccc3nc(ccc23)-c2cn(nn2)-c2ccc(O)c(F)c2)c1

InChI Key InChIKey=RXHQCISHMPQZDT-UHFFFAOYSA-N

Data  6 KI

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50206092   

TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  14nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli assessed as borate-enol complex formation using 4-hydroxypheny...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  14nMAssay Description:Inhibition of recombinant human MIF tautomerase activity using 4-hydroxyphenyl pyruvic acid (HPP) as substrate pre-incubated for 30 mins and followed...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  23nMAssay Description:Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  23nMAssay Description:Data obtained for the Example compounds, obtained using the methods described in Example B.More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  57nMAssay Description:Inhibition of recombinant human MIF tautomerase activity expressed in Escherichia coli using 4-hydroxyphenyl pyruvic acid as substrate preincubated f...More data for this Ligand-Target Pair
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Yale University

Curated by ChEMBL
LigandPNGBDBM50206092(CHEMBL3917143 | US10336721, Example 32 | US1096819...)
Affinity DataKi:  57nMAssay Description:Inhibition of recombinant human MIF expressed in Escherichia coli using HPP as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair